Growth factor receptors: targets for gene therapy and immunotherapy for cancer treatment Review Article
نویسندگان
چکیده
Angiogenesis has a crucial role in the invasion, growth and metastasis of solid tumors. Known angiogenic growth factors derived from tumors and vascular cells include VEGF, FGF, Ang-1, Ang-2, EGF, IGF and PDGF. Angiogenic growth factors bind to receptors with tyrosine kinase activity (RTK). These RTKs are overexpressed or mutated in a variety of human cancers, therefore they represent a potential target for anti-cancer therapy. Recent advances in the fields of gene therapy and molecular biology can be applied to design new vaccines and antitumor therapies for the treatment of cancer. In this review, the use of RTKs for anti-angiogenic immunotherapy and antiangiogenic gene therapy is described, followed by a comparison among several gene delivery methods.
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